Nonparametric Procedures for Finding the Minimum Effective Dose in Each of Several Group
نویسندگان
چکیده
منابع مشابه
Nonparametric procedures for simultaneous identification of the minimum effective dose in each of several groups.
This paper considers the extension of the dose finding problem in a one-way layout setting to the case of several groups, in which the main goal is to identify the minimum effective dose (MED) of each group simultaneously. We propose two nonparametric procedures using the respective pairwise- and Helmert-type two-sample Mann-Whitney statistics, which are applied in a step-down testing scheme fo...
متن کاملNonparametric identification of the minimum effective dose.
We consider identifying the minimum effective dose (MED) in a dose-response study, where the MED is defined to be the lowest dose level producing an effect over that of the zero-dose control. Proposed herein is a nonparametric procedure based on the Mann-Whitney statistic incorporated with the step-down closed testing scheme. A numerical example demonstrates the feasibility of the proposed nonp...
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Nonparametric Identification of the Minimum Effective Dose for Randomized Block Designs
One primary purpose in a dose–response study for drug development is to identify the minimum effective dose (MED), which is the lowest dose level producing an effect over that of the zero-dose control. Proposed herein is a nonparametric step-down closed testing procedure for identifying the MED in a randomized block design with one or more observations per cell. The associated p-value of the id...
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The problem of identifying the lowest dose level for which the mean response differs from that at the zero dose level is considered. A general framework for stepwise testing procedures that use contrasts among the dose level means is proposed. Using this framework, several new procedures are derived. These and some existing procedures, including that of Williams (1971, Biometrics 27, 103-117; 1...
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ژورنال
عنوان ژورنال: Communications for Statistical Applications and Methods
سال: 2012
ISSN: 2287-7843
DOI: 10.5351/ckss.2012.19.1.033